Journal article
Quantification of the dynamics of antibody response to malaria to inform sero-surveillance in pregnant women
ADVTT Dharmaratne, S Dini, K O’Flaherty, DJ Price, J Beeson, R McGready, F Nosten, FJI Fowkes, JA Simpson, SG Zaloumis
Malaria Journal | BMC | Published : 2022
Abstract
Background: Malaria remains a major public health threat and tools sensitive to detect infections in low malaria transmission areas are needed to progress elimination efforts. Pregnant women are particularly vulnerable to malaria infections. Throughout pregnancy they access routine antenatal care, presenting a unique sentinel population to apply novel sero-surveillance tools to measure malaria transmission. The aim of this study was to quantify the dynamic antibody responses to multiple antigens during pregnancy so as to identify a single or multiple antibody response of exposure to malaria in pregnancy. Methods: This study involved a secondary analysis of antibody responses to six parasite ..
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Awarded by Wellcome Trust
Funding Acknowledgements
A.D.V. Tharkeshi T. Dharmaratne is funded by the University of Melbourne (Melbourne Research Scholarship) for education. The funder had no role in the design of the study, collection, analysis and interpretation of data or writing the manuscript. This work is supported in part by the Australian Centre for Research Excellence in Malaria Elimination, funded by the NHMRC (1134989). JAS is funded by an Australian National Health and Medical Research Council of Australia (NHMRC) Investigator Grant (1196068), FJIF by a NHMRC Career Development Fellowship (1166753), and JGB by a NHMRC Investigator Grant (1173046). The Shoklo Malaria Research Unit is part of the Wellcome Trust Mahidol University Oxford Tropical Medicine Research Unit, which is funded by the Wellcome Trust 220211. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.